Development of Novel PD1/PD-L1 Antagonists Using Circular Cys-Knotted Micro Proteins.

摘要

During this first year we have constructed genetically-encoded libraries using the loops 1 and 5 of cyclotide MCoTI-I. We have also accomplished the design and expression of a FRET-based reporter to screen antagonists for the PD-1/PD-L1 complex.