Development and Optimization of a Dedicated, Hybrid Dual-Modality SPECT- CmT System for Improved Breast Lesion Diagnosis

摘要

The overall objective of this project is to implement a dual- modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the detection and staging of breast cancer, monitoring of treatment therapies, and improving surgical biopsy guidance. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in localizing the radioactive uptake of a tumor from the emission image by using the anatomical structure from the transmission image. In the second year, CmT artifacts due to the lateral offset geometry and scatter were investigated. Using the data acquisition sequence developed in Year 1, a couple of patient studies were also completed to demonstrate the strength in 3D volumetric dual-modality imaging with the dedicated SPECT-CmT breast scanner. Other aspects of the training program have been initiated including acceptance of one manuscript to a peer-reviewed journal and presentations at various local and international conferences.