Mercapto-Oximes as Capture Molecules for Detection of Nerve Agents Using Surface-Enhanced Raman Spectroscopy

摘要

Two compounds, 4-methylthiobenzaldehyde oxime and 4-thiobenzaldehyde oxime, were synthesized for use as capture molecules for applications using surface-enhanced Raman as a means of detection. The thioether moiety was successfully attached to the silver nanoparticle substrate as evidenced by the change in the resulting spectrum. The oxime was shown to be reactive toward the nerve agent GD (Soman) in basic solution, as monitored by (31)P NMR.