Veno-venous Extracorporeal CO2 Removal: Can We Reduce Dependence on Mechanical Ventilation During En-route Care.

摘要

Casualties with lung failure are mechanically ventilated during aero- medical evacuation to the continental USA. Positive-pressure mechanical ventilation is potentially injurious to the lung. Consequences of contemporary lung-protective strategies may include cardiovascular instability, use of high fraction of inspired O2, hypoventilation, hypercarbia, and acidosis. These effects may complicate patient management, motivating a search for better lung- replacement approaches. We investigated the ability of a novel extracorporeal veno-venous CO2 removal (V2CO2R) device to reduce minute ventilation (MV) while maintaining normocarbia. Our goal was to explore the potential utility of this technology to reduce dependence on mechanical ventilation during en-route care.