Molecular Epidemiology of Emerging Adenovirus 14 Associated Respiratory Disease in the United States.

摘要

First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered a rare respiratory HAdV. With no precedent of circulation in North America, HAdV-14 has been isolated in the United States since 2003 from military and civilian cases of ARD of variable severity. Genomic analysis of isolates representing different locations and circulation dates showed all examined viruses to be identical and to belong to a new genome type designated HAdV-14a1. The alignment of E1A, hexon, and fiber gene sequences with those of other B2 HAdVs suggests that HAdV-14a1 has arisen from recombination events between HAdV-11 and HAdV-14p strains. A 6 base pair deletion near the predicted binding site of the fiber gene is, so far, the only distinct genetic characteristic of HAdV-14. The current documented geographic distribution of HAdV-14a1-associated ARD involves 14 US states but no Canadian provinces.