Mission Connect Translational MTBI Translational Research Consortium

摘要

In this study we use Magnetoencephalography (MEG) to detect and characterize focal abnormalities in neurophysiological function in patients with mTBI and PTSD for the purpose of distinguishing between the two. MEG is a completely non-invasive imaging modality which is able to provide information regarding focal abnormalities in the brain. MEG has been shown to be sensitive to cognitive complaints in patients with mTBI. In addition neurophysiological abnormalities differentiate patients with mTBI and PTSD in some studies. We are also exploring the relationship between diffusion tensor imaging (DTI) and MEG findings. While MEG provides data regarding focal abnormalities in neural response in the cortex, DTI reveals the status of white matter tracts that form the intracortical connections. Thus, MEG, in combination with DTI, may lead to identification of more distinct, replicable patterns of brain abnormalities in subjects with PTSD and mTBI that may lead to better differentiation between these groups of patients, as well as from patients with a combination of both disorders.