Absorption, Distribution, Metabolism, and Excretion of 14C-RDX Following Oral Administration to Minipigs

摘要

The tissue distribution. elimination, and metabolism of radioactivity were examined following a single oral administration of 14C-RDX, at a target dose of 45 mg/kg, to male and female Yucatan minipigs. Blood, urine, and feces were collected through 24 hours postdose. Blood, plasma, selected tissues, urine, and feces were analyzed for total radioactivity. Following dose administration, all animals vomited. Animals vomited at various times over the course of the study. Concentrations of 14C-RDX-derived radioactivity in plasma reached maximum levels (Cmax) at 12 hours postdose for both males and one female. Blood and plasma concentrations for the second female reached Cmax at 6 hours postdose. The plasma Cmax values for males ranged from 8.76 to 18.3 ug equivalents 14C-RDX/g, and in females values ranged from 8.54 to 10.0 ug equivalents 14C-RDX/g. The distribution of 14C-RDX-derived radioactivity was extensive, with drug derived radioactivity quantifiable in all analyzed tissues at 24 hours postdose. (continued).