Bone Mass Gained in Response to External Loading is Preserved for Several Weeks Following Cessation of Loading in 10 Week C57BL/6J Mice

摘要

Dynamic loads lead to increases in bone mass. How long these gains are maintained after cessation of loading, however is not fully understood. A long term study was performed in which skeletal changes were monitored by pQCT every 2-4 weeks (wks) for a 12 wk period after application of external loading using four-point bending device on 10 wk old female C57BL/6J mice. 2 wks of loading caused 15-40% increase in bone parameters (vBMD), cross sectional area (CSA) and bone strength (yield load, maximum load and toughness). Positive correlations between these two parameters (r= 0.72 to 0.88 p).