Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers with and without PTSD.

摘要

This project is a 12-week randomized controlled trial (RCT) of prazosin for AUD in 200 OIF/OEF soldiers both with and without comorbid PTSD enrolled in the Alcohol and Substance Abuse Program (ASAP) at Madigan Health Care System/Joint Base Lewis McChord. The aims of this trial are 1) to determine prazosin's efficacy for AUD in OIF/OEF soldiers participating in outpatient AUD treatment and 2) to determine if the presence of PTSD affects prazosin efficacy for AUD. In the first year of the study, the protocol was extensively review and recently approved by the VA Puget Sound IRB. This approval was necessary before the Madigan IRB would review the protocol. Madigan IRB has now accepted the study's application and we anticipate their approval by end of November 2013; this would allow an early December 2013 start of participant randomization.