Pluridirectional High-Energy Agile Scanning Electron Radiotherapy (PHASER): Extremely Rapid Treatment for Early Lung Cancer.

摘要

We propose to develop a new type of radiotherapy (RT) system for early stage lung cancer using rapidly scanned beams from many directions through electromagnetic steering with no mechanical moving parts, referred to as pluridirectional high-energy agile scanning electron radiotherapy (PHASER) . Such a system would be similar in size and cost to commonly available systems, but would deliver an entire treatment of high-dose RT in less than one second, and with even sharper dose sculpting than the current state-of-the-art. In addition, extremely rapid radiation delivery may have a more effective biological impact on tumors for the same radiation dose. We have established a unique multidisciplinary collaboration between Stanford University Department of Radiation Oncology and the Accelerator Research Division at Stanford Linear Accelerator Center (SLAC) National Accelerator Laboratory, to design such a system.