Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide.

摘要

Approximately 232,000 new cases and 227,000 deaths occur worldwide annually from pancreatic cancer, including 37,700 cases and 34,200 deaths in the US alone. The possibility that Vitamin D might play a role in the etiology of pancreatic cancer was raised by studies showing that populations living at higher latitudes, or having lower prediagnostic serum 25-hydroxyvitamin D 25(OH)D levels, have higher incidence rates of various cancers. Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions.