Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

摘要

The goal of my project as outlined in the original application is to analyze the role of Protein Kinase D (PKD) in breast cancer cell motility, the phenotype critical for metastasis. The work I have conducted includes the demonstration that loss of PKD in a number of highly metastatic breast cancer cell lines results in a migration defect. I have also discovered a novel substrate of PKD that mediates growth factor signals to control the cell motility.