Individual Differences in Diabetes Risk: Role of Sleep Disturbances

摘要

We have performed the spectral analysis of the sleep EEG in what is likely the largest group of subjects ever assembled and have demonstrated marked effects of age, sex and ethnicity. In these healthy non-obese volunteers who had demographics similar to the demographics of active duty Army personnel, BMI did not impact SWA. Between the ages of 21 and 30, there are large inter- individual variations in SWA that are only partly predicted by sex and ethnicity. Our hypothesis is that these individual differences may partly predict diabetes risk. We have demonstrated the feasibility of the clinical study and successfully obtained all planned assessments. The effort to increase our data base will be valuable to the entire project. While progressing through the analytical and experimental work, we have prepared two reviews on sleep loss and the risk of obesity and diabetes.