Development of Convergence Nanoparticles (Phase II): Detection and Therapeutics of Pathogen Targets by Using Multi-Mode Hybrid Nanoparticle Probe

摘要

Various kinds of pathogens and diseases are now threatening human lives, and their precise and accurate detection and imaging are important to prevent the diseases as well as to understand the biological phenomena. Here we reported a multi-mode nanoprobe system which simultaneously provided highly sensitive detection, imaging, and therapeutic functions in treating of pathogens or diseases. The multi-mode probe consisted of magnetic nanoparticle, targeting molecules, fluorescence tag, and radionuclide and each modality complemented each other to not only increase the detection sensitivity but also eventually to enable the false-free detection of pathogens and disease. Concurrently, the multi-mode nanoparticle also provided high therapeutic effect through combination with biological molecules (e.g. siRNA) or by using heat generation effect of magnetic component.