Polychlorinated Biphenyls, Organochlorines & PD Risk: A Case Control Study in Alaskan Natives

摘要

The intent of this proposal is to conduct a case-control study of Parkinson s disease (PD) among Alaska Natives to determine the association of exposure to polychlorinated biphenyl (PCBs) residues, organochlorine pesticides and methylmercury with PD. The hypothesis is that increased exposure to these compounds will be associated with an increased risk of PD. Exposure will be determined by direct measurement of serum levels, as these compounds are persistent in body tissues. In addition, lifelong exposure will be estimated by structured interview, including a dietary history with specific attention to intake of fish, marine mammals and wild game, known sources of bioconcentration of these environmentally persistent compounds. The project is being conducted in two phases. Phase 1 is a developmental period and is complete for study conduct statewide. The specific aspects of the study design were established, detailed protocols were developed, and Institutional Review Board (IRB) approval was obtained. Phase 2, conduct of the case-control study, is now in progress statewide.