Antioxidant Micronutrients: Therapeutic Counter Measures for Chemical Agents

摘要

The results of the first phase of HD study suggested that exposure to HD increased lung damage in rats by increasing the levels of oxidative damage and pro-inflammatory cytokines, whereas antioxidant treatment before HD exposure reduced lung damage by decreasing the levels of oxidative damage and inflammation. Among antioxidants, plasma levels of alpha-tocopherol were the most reliable indicator of antioxidant consumption. However, careful analysis of data revealed some problems that did not allow making any firm conclusion regarding the efficacy of antioxidants in reducing HD-induced lung damage. These problems included (a) high incidence of lung lesions in untreated animals, gavage route of administration aggravating lung lesions, and some doses of antioxidants aggravating HD-induced toxicity. These problems will be avoided in the second phase of the HD study.