Genetically Modified Porcine Skin Grafts for Treatment of Severe Burn Injuries

摘要

The most significant research findings in this time period include: 1) data supporting the effectiveness of skin grafts from genetically-modified swine transplanted onto full-thickness wounds on baboons when compared to the standard treatment (allogeneic skin); 2) that the use of these swine skin grafts will not sensitize the recipientto the use of a subsequent allogeneic graft if needed for prolonged wound coverage; 3) that topical immunosuppression initiated immediately after grafting may prevent graft vascularization and should therefore be delayed; 4) that systemic immunosuppression enhances the duration of survival of these swine grafts; 5) that genetically-modified porcine skin grafts prevent fluid losses as effectively as allogeneic skin grafts. These findings demonstrate that skin from genetically-modified miniature swine may provide an effective and readily-available temporary biologic cover for severe burn injuries, typical of those sustained in the battlefield.