Plant Colloids for Evaluation as Plasma Extenders and for Complexing with Protein Sparing Substances.

摘要

Animal studies with a series of small batches of glycerol pectate have shown good results. The degree of esterification was found to have an effect on the rate of recovery of hemorrhaged dogs and on the final blood pressure attained in vivo. Preparations with 90% and higher ester content were either slow in restoring the blood pressure or failed because of insufficient oncotic pressure. Similar to previous experience with propylene glycol pectate, partial saponification of such highly esterified glycerol pectate preparations to approximately 85% ester content resulted in a marked increase in oncotic pressure and brought about the desired response in hemorrhaged dogs. In spite of the apparent similarity of the two pectin derivatives, propylene glycol pectate and glycerol pectate, the glycerol ester proved decidedly superior in animal testing and because of the better water solutbility of the glycerol ester water solutions are easily prepared. (Author)