Effects of Methyl Alcohol on Cerebral Blood Flow and Metabolism: Observations During and after Acute Intoxication

摘要

Five patients with acute methyl alcohol poisoning were studied during the 1951 outbreak of this form of intoxication in Atlanta, Georgia. The cerebral blood flow and oxygen consumption was studied by the nitrous oxide method of Kety and Schmidt. Mean blood flow through the brain and oxygen uptake of the brain were reduced 30 per cent below normal barriers at the time of acute intoxication, and one week later both of these functions had improved in the four surviving patients but were still 14 per cent below normal. The depression of cerebral metabolism showed poor correlation with the reported amount of methanol ingested. (Author)