Detection of Certain Serologic Imbalances in Human Sera by Agar Column Analyses.

摘要

The detection of normal and abnormal human sera by quantitative analyses of agar column diffusion patterns has been confirmed and amplified. Baseline precipitin patterns from 29 sera, assumed to be normal, were compared with diffusion spectra of 131 sera from hospitalized subjects. The same fast-moving faint zone, previously observed and believed to be associated with an increased concentration of mucoprotein, was evident. Diffusion data on this precipitin system, together with the data associated with albumin and globulins, were analyzed in order to detect certain serologic imbalances. These analyses showed serologic imbalances in hospitalized subjects in 36 percent more cases than was shown by the usual clinical C-reactive protein test. The results paralleled the physician's estimate of the stress produced by the particular disease state or condition.