Blood Ph and PCO2 Homeostasis in Chronic Respiratory Acidosis Related to the Use of Amine and Other Buffers

摘要

The problem of the control of carbon dioxide in the submarine atmosphere is discussed, especially the aspect of using amine buffers for control of this situation. In World War II, when no adequate CO2 removal equipment existed, concentrations of 3-5% and to be tolerated over extended periods. Attempts to remedy the situation by using alkaline buffers were made and found helpful only in alleviating symptoms related to the pH changes of the uncompensated phase of respiratory acidosis. Results of prolonged exposure to 1.5% CO2 (Operation Hideout) demonstrated that elevated pCO2 persisting during the compensated phase of respiratory acidosis has significant effects on a number of physiological functions, independent of pH, and this condition is not amenable to treatment by amine buffers. (Author)