Alteration of Response of Dogs to Cerebral Aeroemboli by Pretreatment with Procaine Hydrochloride

摘要

The effect of pretreatment with intracarotid procaine hydrochloride on the consequences of intracarotid injection of air was studied in dogs. The results indicate that this pretreatment provides a protective effect. This effect is presumably due to the prevention of vascular spasm usually caused by aeroemboli. The results are indeed not conclusive with regard to the beneficial effect of intra-arterial procaine therapy in clinical cases of aeroemboli, but it would appear that, in view of the lack of deleterious effects in anesthetized subjects, its use could be considered in selected cases. Further laboratory investigation is warranted. (Author)