Development of a Continuous Cell Line from Normal Dog Liver and its Susceptibility to Viruses.

摘要

A continuous line of cells was developed from a primary culture of new-born dog liver. The cells were inoculated with five types of Coxsackie B virus, three types of poliovirus, nine types of ECHO virus, and six miscellaneous viruses. Nineteen of these produced cytopathic effect without need of adaptation to the cells. One virus became adapted after four passages, one lost its ability to destroy the cells after the first passage and two failed to grow even after several blind passages.