MECHANISMS OF ACTION OF THE INSECTICIDE ENDRIN

摘要

Cardiovascular effects of endrin insecticide are obscure. Experiments to investigate these phenomena were carried out on dogs and suggested mechanisms of action have been pro-posed;Results show that acute administration of endrin produces bradycardia, hypertension, copious salivation, hyper excitability, tonicclonic convulsions, increased body temperature, leukocytosis, hem concentration and decreased blood pH. Cerebral venous pressure and cerebrospinal .fluid pressure elevations are also prominent features of endrin poisoning Al-though most of these effects appear to be caused by endrin acting directly on the central nervous system some may result secondarily from altered cerebral hemodynamic. A schema of the possible mechanism of -action of endrin has been presented.