Micro-Fabricated Perforated Polymer Devices for Long-Term Drug Delivery.

摘要

Fabrication techniques have been developed to produce a perforated polymer microtube as a drug delivery device. The technique consists of first forming a silicon platform with trenches and alignment marks to hold the tubes for subsequent processing. Photolithography and reactive ion etching with an inductively coupled plasma source were used to fabricate micro holes on the surface of polyimide tubes. Several materials have been used to form the etching mask, including titanium film deposited by e-beam evaporation and SiO2 and SiNx films deposited by high-density plasma chemical vapor deposition (HDPCVD). Three equidistant holes of 20 m in diameter were fabricated on polyimide tubes (I.D. = 125 m). The perforated tubes were loaded with ethinyl estradiol and tested for drug release in phosphate buffered saline (pH=7.1) at 37 C. Zero order release was observed over a period of 30 days with a potential to be extended to 4 years.