THE METABOLISM OF HORMONAL STEROIDS AND OF EPINEPHRINE BY IMMATURE CHIMPANZEES

摘要

Results are reported on the metabolism of tracer doses of adrenocortical and gonadal steroid hormones by ten immature chimpanzees. Values for the daily excretion of major metabolites of these hormones have been obtained, and where possible the endogenous secretion rate of the steroids in the chimpanzees has been estimated by isotope dilution. Data are reported on the metabolism of epinephrine labeled at two different sites in the molecule, and observations and comment are provided on selected cardiovascular effects of epinephrine infusion. The results on both the steroids and epinephrine have been compared to those obtained by similar methods in human subjects, and some conclusions have been drawn on the apparent suitability of the chimpanzee as a prototype for man in biological studies. (Author)