Atropine Detoxication during Hypothermia by the Isolated Perfused Rat Liver

摘要

Considerable information has been gained on the metabolism of C14 atropine by the isolated, perfused rat liver under normothermic and hypothermic conditions. The half-life of the drug is prolonged under hypothermic conditions, and the per cent of drug remaining in the plasma 4 hours after administration is greater at the low temperatures. Four hour, after administration, the liver perfused at 17.5 has secreted only 2o％ as much C14 into the bile as has the liver perfused at 37°C. At 25°C, bile collected 4 hours after drug administration shows about 60% of the amount secreted at normothermic temper¬atures. At all temperatures, the material appearing in the bile is an altered form of the drug and none of the 5 chromatographically separable compounds is tropic acid the perfused preparation than by the intact rat.