Certain Peculiarities of the Adaptation Process to Streptomycin in Various Strains of Pasteurella Pestis on Nutrient Media

摘要

Four types of Pasteurella pestis were pointed out: Sensitive, weakly resistant, highly resistant dependent and highly resistant independent. The appearance and stabilization of these forms was determined by the concentration of streptomycin in the media on which the populations of strains under study were cultivated. A study of the peculiarities of dynamics of the development of streptomycin resistant strains of Pasteurella pestis during serial seedings on Hottinger agar with gradually increasing content of antibiotic, made it possible to differentiate three types of adaptation of bacterial populations to streptomycin: (1) Full type: Sensitive, weakly sensitive, highly resistant dependent form; (2) Transitory type: Sensitive, weakly resistant independent form; and (3) Reduced type: Sensitive, highly resistant independent form. (Author)