Effects of Variations in Carbohydrate, Protein and Fat Intake on Characteristics of Growth of Rats

摘要

Rats of the Sprague Dawley and Osborne Mendel strains were fed purified rations containing 4.5% and 60% fat for periods ranging from 25 to 40 weeks. For both strains there was a significantly greater average weight gain with the higher fat intake than with the lower fat intake. The Osborne Mendel rats gained more weight than the other strain and it was found that at least 50 per cent of the Osborne Mendel group on the high fat diet were obese after 25 weeks. There was no significant difference between the caloric intakes of the two groups for either experiment. Studies of the output of C14O2 and C14 incorporation into tissue lipids following injection of acetate-1C14 failed to differentiate the two groups in either study. Body composition values for the Osborne Mendel rats showed an increased deposition of fat and a diminished amount of protein and moisture in the rats fed the high fat diet as compared with those fed the high carbohydrate diet. An extensive review of the literature is included. (Author)