Immunological Effectiveness of Burcellosis Vaccination

摘要

A study was undertaken of the immunological efficacy of the live brucellosis vaccines by vaccinating workers of a meat plant with subcutaneous and skin dry live vaccines of the Gamaleya Institute of Epidemiology and Microbiology of the USSR Academy of Medical Sciences. Serological and allergic shifts were determined 1-3, 3-6, 6-9 months later as well as after 9 months. These vaccines (both subcutaneous and skin) proved to provoke only mild untoward reaction in response to their administration. In 3-6 months the highest percentage (95 per cent) of immune individuals was revealed in persons immunized subcutaneously, and in 1-3 months among the skin vaccinated ones. Immunological reconstruction in persons vaccinated subcutaneously was more prolonged than in those vaccinated by the skin method (for over 9 months - in 49 and in 86.6 per cent of the cases respectively). It was confirmed that the body immunological reconstruction in subcutaneously vaccinated persons followed the general regularities of the infectious process development in brucellosis, whereas in skin immunization, allergic reconstruction occured at the early periods, and then disappeared. The data obtained indicated that Huddleson's reaction could serve as a relative index of immunological efficacy of brucellosis vaccines. High antibody titres according to Wright's reaction (1:400) in the blood serum of the vaccinated individuals pointed to the necessity of careful approach to brucellosis diagnosis in the vaccinated individuals. (Author)