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PRESENCE OF DONOR SPECIFIC γ-GLOBULINS IN SERA OF ALLOGENEIC MOUSE RADIATION CHIMERAS

机译:供体特异性γ-球蛋白在同种异体小鼠辐射体系中的存在

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Young adult DBA/2 mice received a single whole body X-ray exposure of 840 rad (an otherwise lethal dose) followed by an intravenous injection of 8 x 106 bone marrow cells from normal (C3H x DBA/2)F1 donors. Control groups included syngeneic (isogenic) chimeras, i.e., DBA/2 mice which received 840 rad plus an injection of 8 x 10 DBA/2 marrow cells. Blood serum from these chimeras was collected at times up to 9 months postirradiation, and analysed for total 7-glbbulin levels and for specific donor or host type y-globulin isoantigens. Marrow-donor type 7-globulins (Igal) were found in the serum of the allogeneic chimeras at various times up to 9 months after irradiation.

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