The Effect of Ionizing Radiation of Hepatic Regeneration in White Mice after Brief and Chronic Irradiation

摘要

This work compares the reaction of the mammalian liver to irradiation with different dose rates where this concerns the level of physiological regeneration of that organ. Using regeneration of white mice livers after partial hepatectomy as a criterion, the level of hepatic injury during short- and longterm irradiation of the animals by Co 60 gamma rays was studied. Tests showed that when the dose rate is lowered and the irridation is extended over a month the radiation effect is lost. It is not clear whether this depends on reparation having time to compensate for radiation injury in the case of chronic, or if with a single exposure regeneration occurs concomitantly with radiation sickness. In chronic irradiation radiation sickness this was not expressed and could not influence the course of regeneration. This data supports the theory that local irradiation suppresses hepatic regeneration only with very large doses of radiation.