Investigation of the Mechanism of Action of Ryanodine on Mammalian Skeletal Muscle

摘要

Efforts to isolate, from granule suspensions incubated with MG(++) and ATP, a chemical substance capable of relaxing contracted muscle fibers were unsuccessful. Conditions were established under which ryanodine increased by a factor of two or more the time required for fiber bundles to relax after addition of calcium to the bath containing ATP, MG(++) and granules.