Therapeutic Properties of Blood Plasma in the Therapy of Tourniquet Shock

摘要

A significant difference in therapeutic effectiveness was demonstrated in the treatment of rat tourniquet trauma between reconstituted lyophilized aged human plasma (RLAP) and other clinically used albumin containing protein electrolyte solutions (Albumisol, Plasmanate, Agamma Human Serum). RLAP in this experimental system provides a much superior survival rate even though the degree of plasma volume expansion provided by the two types of solutions is the same as long as 4 hours after tourniquet release. Because recently collected human plasma allows no survival after this trauma when given in the same way, it is believed that something deleterious is removed from the fresh plasma or something beneficial is produced in it during aging. The bulk of evidence to this point supports the latter hypothesis. Five Cohn fractions (I, II, IV-l, IV-4, V) have been suspended in a sodium chloride, sodium bicarbonate solution and produced the same survival results achieved by the control plasma (RLAP). Fraction III in the mixture is not required. (Author)