ANTIARRHYTHMIC ACTIVITY OF ANTAZOLINE AND ITS APPLICATION TO THE CONTROL OF HYPOTHERMIC VENTRICULAR FIBRILLATION

摘要

The chemistry and general pharmacology of antazoline and experimental studies employing it are reviewed to determine the antiarrhythmic activity and the protective effect of antazoline against hypothermic ventricular fibrillation. In hypothermic ventricular fibrillation and in clinically observed heart disorders, the antiarrhythmic activity of antazoline was often superior to other pharmacological agents, including quinidine. The incidence of side effects, notably nausea or vomiting, was found to be related to the dosage. Since the basis of the antiarrhythmic activity of antazoline is essentially unknown, further studies in this direction are warranted to provide for sys¬tematic development of more effective compounds.