BIOCHEMICAL ASPECTS OF THE INHIBITION OF LIVER REGENERATION BY TRANSFUSION OF HEPATECTOMIZED RATS WITH BLOOD FROM NORMAL RATS

摘要

Because of the rapidity of its regenerative process and the synchrony of the first mitotic waves induced by partial keratectomy, regenerating rat liver is a very suitable material for studying control mechanisms of growth. Recent studies by massive transfusion techniques in this laboratory have shown the presence of a humoral factor which plays a role in the control of MNA. Synthesis in regenerating liver. Therefore, it is the purpose of this communication to describe the effect of massive transfusion on the enzymes involved in DMA synthesis, messenger RNA synthesis, and also on the capacity of microsome to inhibit DNA polymerase in vitro.