BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM

摘要

Botulinum antitoxin, types A and B, was administered irtravenously to monkeys after appearance of toxic signs resulting from administration of 2.5 to 5.0 LD50's of botulinum toxin. Recoveries were realized in 11 out of 15 animals when liquid food and fluids were forced during the aphagia period. Only one out of six monkeys survived when no supportive treatment was applied. The survivor had received only 2.5 LD50's of toxin. The intravenous administration of antitoxin soon after detection of toxic signs can save most monkeys. Daily intragastric feedings, vitamins, and antibiotics must be included in the therapeutic treatment.