The Effect of Dimercaptopropanol (British Anti-Lewisite) on the Toxicity of Oxygen at Six Atmospheres' Pressure on White Male Rats

摘要

Six groups of ten white male Holtzman rats were given doses of 10, 25, 40, 50, 75, and 100 mg./kg., respectively, of British anti-lewisite. Time of onset of the first convulsions after the animals were exposed to 6 atmospheres of oxygen and the survival time were compared with those of fifty control animals. As the dose was increased to 40 mg./kg., both the onset of convulsions and the survival time were increased to a peak and then decreased with further increase in dosage until they reached almost control levels again at the dose of 100 mg./kg. Another group of animals was given equivalent doses of the vehicle in which British anti-lewisite was dissolved and of an inactive analog of British anti-lewisite (glycerin). It was shown that the effect seen was not due to either the vehicle or the inactive analog. (Author)