Biosensing Technics for Human Detection. II. The Frog Skin Transducer: A Continuous Flow System for Making Critical Measurements

摘要

Earlier results in which transmembrane potential changes were elicited across frog belly skin by a number of compounds were duplicated. Four additional compounds were tested, including dimethyl sulfoxide. Dimethyl sulfoxide has no apparent adjuvant action when tested with urea. Measurements were attempted using low concentrations of test compounds by an expanded scale technique. The static 2-chamber cell is not suitable for this type of measurement. A continuous flow cell was assembled and tested. This system should permit critical measurement of effects of low concentrations of test substances and it also provides a point of departure for design studies leading to development of a practicable field detection instrument. (Author)