Effect of Adenosinetriphosphoric Acid (Atp) on the Metabolism of Phosphoproteines in the Liver at Radiation Infliction

摘要

During the incubation of normal liver tissue, when ATP is added in amount of 0.35 m moles per 1 g of tissue are observed increases in the amount and intensity of restoration of phosphoproteine phosphorus. During the incubation of samples from liver tissues of animals exposed to lethal dosage of x-ray radiation, the addition of ATP does not affect the content nor intensity of restoration of phosphoproteine phosphorus. The content of ATP in the liver decreases considerably after the animals are exposed to x-ray radiation of lethal capacity. Maximum reduction in amount of ATP is observed on the tenth day of radiation illness. Under the effect of general x-ray radiation the content of phosphorus in phosphoproteines drops on an average to 30-35%, and the restoration intensity in comparison with standard rise on an average by 20% in all investigated periods after the exposure. The content of inorganic phosphorus in liver of exposed animals rises on an average by 20-35%, and the specific activity remains without changes. (Author)