Immunobiological Effectiveness of the Associated Plague, Tularemia and Brucellosis Vaccines in Various Methods of Cutaneous Application

摘要

Conclusions: The indices of the immunobiological reorganization to plague, tularemia and brucellosis in tests on animals and in observations on humans make it possible to consider inoculation with 3 monovaccines simultaneously, but on various sectors of the skin, equivalent in effectiveness to cutaneous inoculation with a mixture of 3 monovaccines and with dry associated trivaccine. In practice it is possible to carry out a simultaneous inoculation against plague, tularemia and brucellosis with dry live monovaccines in a mixture, and also separately. Here it is necessary to avoid inflicting superficial scarifications on the skin and the appearance of blood when rubbing in the vaccine. Insufficiently deep scarifications on the skin are the main cause of a poor result of inoculation not only with live associated, but also with other live bacterial monovaccines. (Author)