Ribo Nucleic Acid Chemistry: A Model System for Ribonucleic Acid Depolymerization and Hydrolysis

摘要

The report summarizes evidence based on the kinetic behavior of ribonucleic acid model systems that a strong stereoelectronic effect operates in nucleophilic attack on phosphorus. The origin of this effect was ascribed to the geometric requirements of pl bond formation pi between phosphorus and oxygen. This theory was investigated by X-ray diffraction studies of the moleuclar structure of a suitable compound. (Author)