THE EFFECT IN STOMACH OF IONIZING RADIATION ON ACID SECRETION POTENTIAL ADENOSINE TRIPHOSPHATE AND PHOSPHOCREATINE IN COMPARISON TO SPLEEN

摘要

Results using an In Vitro rat stomach preparation indicate that gastric acid secretion is stimulated through neurological pathways and induced by both handling and irradiation. The changes in acid secretion occurred independently of alterations in the sodium-potassium dependent potential across the stomach. Despite the two functional radiation effects, there were no gross changes in phosphorylative metabolism in rat stomach, otherwise adenosinetriphosphate and phosphocreatine would have been affected. At the same time, there was the expected irradiation change in spleen ATP, but the spleen phosphocreatine remained unchanged. The latter is a new observation which puts in question some aspects of the current cellular theory of splenic irradiation effects.