X-RAY INDUCED GLOMERULOSCLEROSIS IN RATS:MODIFICATION OF LESION BY FOOD RESTRICTION, UNINEPHRECTOMY, AGE

摘要

The development of glomerulosclerosis WAS mepsured in the kidneys of rets under various conditions of irradiation and growth. Weanling rats whose kidneys were irradiated directly with 1000 red or 2000 red developed glomerulosclerotic lesions in 2 months;one-year old rats showed no evidence of lesions 2 months after irradiation with 2000 rad. In the weanling rat the rapidity of development and severity of the glomerulosclerotic lesions were increased by growth or en¬largement of the kidney subsequent to irradiation, and were solved by growth retardation artificially produced through low-food intake. The induction of glomerulosclerosis by X-irradiation of the kidney is believed to be a latent result of damage to the kid¬ney's vascular system, and that effects of this damage are ac¬centuated in the growing kidney.