The Effect of Monomethylhydrazine with and Without Pyridoxine on Operant Behavior of Primates

摘要

Ten macaque monkeys were trained on a complex behavioral program containing both aversively and appetitively rewarded tasks. A two-phase experimental design was utilized. During Phase I all subjects were repeatedly exposed at one of two dose levels of monomethylhydrazine and pyridoxine HCl. The monomethylhydrazine (i.p.) and pyridoxine HCl (i.m.) injections were administered simultaneously. Phase II was a replication without pyridoxine HCl. Data included behavior on a Sidman avoidance schedule, FR(100:1) and three-stimulus oddity for food, as well as discrete avoidance with both visual and auditory cues. Gross clinical signs were noted. Dose-response and temporal relationships were investigated. Appetitive responding was found to be most sensitive and the differences between Phase I and Phase II provide some evidence that pyridoxine HCl may be effective as a therapeutic agent in situations involving exposure to low levels of monomethylhydrazine. (Author)