Observations on the Effects of Decaborane and Several Potential Antidotes in the Rat

摘要

Rats were injected intraperitoneally with decaborane (B10H14) and observed over a seven-day period to determine their toxic reactions, including death rate. Pyridoxine, pyridoxal, and pargyline (MO-911) were tested in the decaborane-treated rats as antidotes for the observed manifestations of the boron hydride injection. In these studies pyridoxine (1 mmole/kg.) given simultaneously with decaborane prevented the convlusions and hyperactivity usually seen in rats treated with decaborane alone (20 mg./kg.) and caused a significant decrease in the number of deaths. Pargyline, 50 mg./kg., given with the decaborane gave no significant alteration of the CNS symptoms, but significantly reduced the mortality rate. Pyridoxal phosphate and a higher level of pyridoxine (2 mmoles/kg.) were without beneficial effect. Some implications of the data are discussed. (Author)