Alterations of Monoamine Content by Decaborane after Monoamine Oxidase Inhibition by Iproniazid

摘要

Pretreatment of rats with 100 mg. iproniazid/kg. does not prevent the fall of brain and heart norepinephrine content produced by the subsequent injection of 15 mg. decaborane (B10H14)/kg. This phenomenon is in contrast to the effect of the drug combination on rat brain 5-hydroxytryptamine. In this case, pretreatment with iproniazid does prevent the decaborane-mediated decline of brain 5-hydroxytryptamine. The results are discussed in relation to the mechanism of action of decaborane. (Author)