Studies on Chemotherapy and Serodiagnosis for Clonorchis Sinensis Infection

摘要

A previous paper reported that 6 (66.6%) out of 9 cases of clonorchiasis patients treated with 50 mg/kg of 1,4-bis-trichloromethylbenzol for 5 consecutive days, 7 (42.8%) out of 14 with 40 mg/kg and 2 (15.8%) out of 13 with 30 mg/kg were considered to be completely cured. In the present trial, a second mass-treatment of clonorchiasis with 1,4-bis-trichloromethylbenzol was carried out. Ninety-nine patients were treated, dividing them into 3 groups according to the doses, 50 mg/kg, 60 mg/kg and 70 mg/kg, for 5 consecutive days. Follow-up studies for one year after treatment showed complete cure in 21 (67.7%) out of 31 patients with 50 mg/kg, in 23 (83.1%) of 28 with 60 mg/kg and in 27 (87.0%) of 31 with 70 mg/kg. Difference in size of dose produced no difference at all in the incidence and severity of the side effects. Subacute and chronic toxicity tests of the drug were carried out in rats. Adult rats were divided into groups and given 100 mg/kg, 200 mg/kg, 300 mg/kg and 500 mg/kg, respectively, daily by mouth for 4 weeks and another group was given 100 mg/kg daily for 12 weeks. The administration to rats of 1,4-bis-trichloromethylbenzol in dose of 100 mg/kg daily for 12 weeks produced no toxicity at all; however, in the dose of 200 mg/kg or more daily, the administration for even 4 weeks produced toxicity in rats. It is concluded from the result that there is practically no danger so long as its administration in the order of 100 mg/kg or less daily for 5 days. (Author)