Input-Output Relations for Axo-Somatic Activation in a Neuron Model

摘要

Previous experimental findings have suggested that axo-dendritic activation is the primary source of nonlinear integration among input pulses while axo-somatic activation mediates a relatively inflexible driving influence on the cell. Our own previous work has examined a theoretical basis for this distinction and presented a model to account for the nonlinear properties of axo-dendritic activation. The present paper addresses the properties of axo-somatic activation with a digital-computer simulation of the elicitation of spikes by postsynaptic potentials. Input-output relations for regular and irregular temporal patterns of excitatory activation, and for combined excitatory and inhibitory activation are presented. The results corroborate the hypothesis. (Author)