Preparative Scale Gas-Liquid Chromatography of Substituted Diazirines

摘要

The heretofore unseparated reaction mixture resulting from the reaction of acetamidine hydrochloride with sodium hypobromite has been resolved into two pure substances: 3-chloro-3-methyldiazirine and 3-bromo-3-methyldiazirine, using preparative scale gas-liquid chromotography (GLC). The general utility of this method of purification has been extended to a series of substituted diazirines. In all cases, the resultant material was free from either contaminants or decomposition products. Product identification was accomplished by utilizing infrared and ultraviolet spectroscopy and mass spectrometry. (Author)